Prolon Longevity
My background
I am Dr. Scott Levine MD. I am double boarded in Internal Medicine and Anti-aging and Regenerative medicine. For more than 20 years I have been developing nutritional supplements to help people improve their health and longevity. For more than thirty years, in a solo practice specializing in Internal Medicine, Anti-Aging, and Advanced Preventative Care, I took care of patients and worked to optimize their health and longevity. I still like to explain things the way I would sitting across from a patient.
On this site, that work includes 360°smartvitamin™️, which I offer as the most diverse and potent antioxidant vitamin, and 360°smart weight®, my patented ultra-high fiber formula. The U.S. Patent Office awarded me U.S. Patent 7,030,092, “Ultra-High Fiber Supplement And Method of Reducing Weight, Cardiovascular Risks And Ingested Toxins,” after I produced blood work and statistical information on my patients showing these improvements. Metabolic health, nutrition, weight, and longevity have been at the center of my work. That is why I recommend only the two approaches below.
I am very advanced in preventative medicine. It is always better to prevent a condition than to try to resolve it. For more than thirty years, I provided the best preventative protection to my patients, and I can uniquely claim that none of my patients had a heart attack, developed heart disease, had a stroke, developed dementia, or developed kidney disease while under my care, though I did treat patients who came to me with these conditions and kept them from getting worse.
Why I recommend only two diets
When the goal is longevity and better metabolic health, I recommend only two diets. I recommend them because they can help with metabolic health, longevity, weight loss, blood cholesterol and other blood lipids, blood sugar, and blood pressure. Those everyday improvements are what I watch for, and they are what I mean when I talk about anti-aging benefits.
Dr. Levine's 360°smart weight®
The Smartest, Healthiest, Safest, Easiest, and Most Effective Way To Lose Weight™.
The first diet I recommend for metabolic health is not technically a diet. It is the addition of a special blend of 5 different kinds of fiber that fill you up with ZERO calories, so you feel full, eat less, and lose weight. After spending years trying to find effective ways to help patients achieve meaningful, long-lasting weight loss, I developed this zero-calorie fiber product as a way to fill people up with healthy fiber. On this diet you can eat what you want, because you will eat less than you had been eating and lose weight. I have amazing testimonials on this product and how it has been life-altering for some. Due to the logistics of packing and shipping, the only way to get it is to reach out directly to me to arrange payment and shipment.
360°smart weight® is my patented, healthy fiber product. You stir the powder into water and drink it. The fiber sends a signal to your brain to stop eating.
US Patent Office granted patent 7,030,092 “Ultra-High Fiber Supplement And Method of Reducing Weight, Cardiovascular Risks And Ingested Toxins.”
- A second patent, U.S. Patent 7,977,319, builds on it.
You can read more, and see how to order, on the 360°smart weight® page.
The Prolon fasting mimicking diet for weight loss and longevity
Fasting can be beneficial to your health. I also tell my patients that if it is not done properly, it can be detrimental. In my clinical experience, a fast that is not done carefully can release a large amount of stored toxins into the bloodstream. It can also cause a significant loss of muscle. That muscle is very hard to replace, and building muscle is critical as you age.
Prolon is the fasting plan I recommend. It is a scientific fasting-mimicking diet, which means it is designed to make your body think it is fasting without actually fasting.1,2 You still eat. It is a 5-day, plant-based meal program from L-Nutra,2,3 developed from research led by Dr. Valter Longo at the University of Southern California.1,2 The published menu is low in calories and protein: vegetable-based soups, energy bars, drinks, snacks, tea, and a micronutrient supplement, eaten for 5 days in a row rather than water only.1,2 The small amount of nutrients in the Prolon meal plan is small enough to keep your body thinking it is fasting, yet it provides enough nutrients that you don't feel like you are fasting.
When I talk with patients about autophagy, I describe it as the body’s cleanup. It clears old, damaged, senescent cells that can reduce metabolic efficiency. Research on prolonged fasting has linked that kind of fast with autophagy, and has also noted that a water-only fast is difficult for most people and can be too extreme. The fasting-mimicking diet was developed to seek those fasting-like effects while you still eat.1 In a randomized trial, generally healthy adults who finished this 5-day plan once a month for 3 months had lower body weight, trunk and total body fat, blood pressure, and IGF-1, a growth factor the study tracked, and no serious adverse effects were reported.2 A 2024 analysis of fasting-mimicking diet trial samples, using the L-Nutra program boxed as Prolon, found that 3 cycles were associated with a 2.5-year decrease in median biological age, independent of weight loss.3
In short, the Prolon fasting mimicking diet allows you to eat specific foods and nutrients during a period in which your body thinks it is fasting, which makes it a comfortable way to enjoy the health benefits fasting can promote. It is one of the most scientifically studied diets, has numerous patents, and allows you to get the benefits of fasting without damaging your body. In my view, mitochondrial health is the key to health and longevity, and this diet helps create mitochondrial health.
Claim your 5-20% discount on ALL Prolon products (opens in a new tab)
Consult your physician before starting any fasting program.
Questions about the discount and who should skip it
How do I get the discount?
Click the green button. The 5-20% provider discount is applied through my provider link.
Who should not do Prolon?
Prolon says not to use the 5-day plan if you are pregnant or breastfeeding, under 18 or over 70, have a BMI under 18.5, have an eating disorder, have an active infection, are malnourished or protein deficient, or have specific dietary restrictions. People with diabetes who use insulin or another glucose-lowering medicine should not start it on their own. If you take medication or have a medical condition, check with your physician first.
How often should it be done?
Prolon's guidance is three cycles, about a month apart, then three to four cycles a year, and not more than once a month. More frequent use has not been tested. Ask your physician what is right for you.
Sources: Prolon, “Is the FMD for me?”; Prolon, “The Ultimate Guide to Fasting” (diabetes and glucose-lowering medicine); Prolon, “How Prolon works” (medical conditions and eating disorders); Prolon 5-day page, “How often should I do the program?”; Prolon FAQ, cycles in a year; Prolon FAQ, once a month.
Last reviewed by Scott Levine MD, November 2026
Research
- Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell Metabolism. 2015;22(1):86-99. doi:10.1016/j.cmet.2015.05.012. PMID: 26094889. https://pmc.ncbi.nlm.nih.gov/articles/PMC4509734/
- Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine. 2017;9(377):eaai8700. doi:10.1126/scitranslmed.aai8700. PMID: 28202779. https://pmc.ncbi.nlm.nih.gov/articles/PMC6816332/
- Brandhorst S, Levine ME, Wei M, Shelehchi M, Morgan TE, Nayak KS, Dorff T, Hong K, Crimmins EM, Cohen P, Longo VD. Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk. Nature Communications. 2024;15(1):1309. doi:10.1038/s41467-024-45260-9. PMID: 38378685. https://pmc.ncbi.nlm.nih.gov/articles/PMC10879164/ https://www.nature.com/articles/s41467-024-45260-9
Claim your 5-20% discount on ALL Prolon products (opens in a new tab)